José Antônio Rocha Gontijo

Early impact of gestational protein restriction on nephrogenesis in male mouse offspring: Role of Autophagy and Apoptosis Mechanisms

This study examines how low-protein diets during pregnancy affect kidney development in male mouse offspring, showing changes in gene expression, autophagy, and nephron numbers by gestational day 18.

Enriched environmental intervention mitigates hippocampal cellularity and behavioral disorders in maternal protein-restricted male rat offspring

This study shows that maternal protein restriction during pregnancy and breastfeeding reduces hippocampal neurons and behavioral issues in male rat offspring, but an enriched environment can reverse these effects.

Impact of maternal protein restriction on hypoxia-inducible factor (HIF) expression in male fetal kidney development

The paper investigates how maternal low-protein diet affects HIF-1 signaling in fetal kidney development, linking it to reduced nephron numbers and impaired renal function.

Precocious hippocampal structural and functional changes in gestational protein-restricted male elderly offspring: an Alzheimer-simile disease model?

This paper investigates the effects of gestational protein restriction on hippocampal structure and function in male offspring, finding accelerated functional decline and AD-like biomarker deposition.

Impact of gestational low-protein intake on embryonic kidney microRNA expression and in the nephron progenitor cells of the male offspring fetus

This study shows that gestational low-protein diet alters miRNA expression and nephron progenitor cell dynamics in fetal male offspring, leading to reduced nephron numbers and renal dysfunction.

miRNAs, target genes expression and morphological analysis on the heart in gestational protein-restricted offspring

This study examines the effects of gestational protein restriction on cardiac morphology and miRNA expression in offspring, finding altered miRNA profiles and gene expression associated with cardiovascular changes.

Gestational low-protein intake enhances the whole kidney miR-192 and miR-200 family expression and epithelial-to-mesenchymal transition in adult male offspring

The paper investigates how maternal low-protein diet affects kidney function in adult male offspring, finding increased miR-192 and miR-200 family expression and EMT markers.