Íscia Lopes‐Cendes

This study uses single-nucleus multiomics to map cell types and molecular changes in MOGHE lesions, identifying disease-specific oligodendrocytes and heterotopic neurons with altered gene expression.

This study uses multi-omics single-cell profiling to identify chromatin and transcriptomic changes in FCD type II, revealing altered cell states and neuronal vulnerability.

This study shows that epileptogenesis disrupts the circadian clock and alters diurnal transcriptomic rhythms in the mouse hippocampus, with implications for human epilepsy.

The paper develops an optimized protocol for cloning unstable plasmids encoding sodium channel subunits, improving plasmid quality and sequence accuracy.

This study uses cell-type deconvolution and single-cell signatures to analyze bulk RNA-seq data from FCD patients, revealing subtype-specific cellular changes, including astrogliosis in FCD IIb.

The paper uses RNA-seq to analyze transcriptomic profiles of rat hippocampal subfields, identifying region-specific marker genes and molecular functions.

This study identifies differentially expressed genes in dorsal and ventral subiculum of rats after preconditioning with perforant pathway stimulation, revealing changes in cholesterol metabolism, synaptic reorganization, and neuroprotection.

This paper identifies seven genome-wide significant loci associated with early neurological instability after acute ischemic stroke, linking excitotoxic genes to poor outcomes.

The paper investigates genetic variation in 27 candidate genes and HLA alleles in 954 admixed Brazilian exomes, identifying common and rare variants potentially influencing SARS-CoV-2 infection and response.

This study shows that gestational low-protein diet alters miRNA expression and nephron progenitor cell dynamics in fetal male offspring, leading to reduced nephron numbers and renal dysfunction.

This study identifies nine genetic loci associated with age at onset in Machado-Joseph disease, suggesting roles for DNA repair and synaptic pathways in disease progression.

The paper identifies genetic loci associated with human cortical structure and finds genetic correlations with neuropsychiatric disorders.