Juan Cortés

Conformational ensembles of flexible multidomain proteins: How close are we to accurate and reliable predictions?

This study evaluates five computational methods for modeling conformational ensembles of flexible multidomain proteins using SAXS data, highlighting discrepancies and biases in their predictions.

Generative design of intrinsically disordered proteins based on conditioned protein language models: Data is the limit

This paper presents a generative framework for designing intrinsically disordered proteins using protein language models, showing that large datasets are essential for accurate conformational control.

Evidence for the Progressive Improvement of All-Atom Force Fields in Reproducing Local Conformational Preferences of Flexible Peptides

The paper evaluates improvements in all-atom force fields for modeling flexible peptides by comparing conformational ensembles to experimental data.

The dependence of the amino acid backbone conformation on the translated synonymous codon is not statistically significant

The paper reanalyzes data from Rosenberg et al. to show that codon usage has no significant effect on dihedral angles in protein structures.

Interplay Between Intrinsically Disordered Proteins and Atomically Precise Gold Nanoclusters Modulates their Optical Properties

This study investigates how intrinsically disordered proteins modulate the optical properties of gold nanoclusters through position-specific anchoring, leading to enhanced photoluminescence.

WASCO: A Wasserstein-based statistical tool to compare conformational ensembles of intrinsically disordered proteins

WASCO compares conformational ensembles of intrinsically disordered proteins using a Wasserstein-based statistical metric to detect residue-level differences.

Exhaustive exploration of the conformational landscape of small cyclic peptides using a robotics approach

The paper introduces a method to explore the conformational landscape of small cyclic peptides and validates it using a drug candidate.