Matteo Paloni

The paper develops a model showing how protein-RNA binding and phase separation interact to influence RNP condensate behavior, revealing RNA's role as a scaffold and explaining condensation dynamics.

The paper evaluates improvements in all-atom force fields for modeling flexible peptides by comparing conformational ensembles to experimental data.

The paper uses solution scattering and simulations to show that Dhh1's modular architecture allows structural heterogeneity while maintaining functional specificity.

This study uses a thermodynamic model to show how enzymatic reactions regulate biomolecular condensates by coupling reaction kinetics to local molecular environments, revealing two general principles.

This study shows that polysomes and mRNA organization control cytoplasmic biophysical properties by affecting diffusivity through translation inhibition and mRNA condensation.

The paper quantifies ion binding to biomolecular condensates using NMR and shows that ion uptake follows water affinity matching, affecting condensate microenvironment and biochemical processes.

This study uses atomistic simulations to show that RNA structure is destabilized in biomolecular condensates due to interactions with peptides, with amino acid composition affecting RNA conformation.