Aurélien Thureau

Conformational ensembles of flexible multidomain proteins: How close are we to accurate and reliable predictions?

This study evaluates five computational methods for modeling conformational ensembles of flexible multidomain proteins using SAXS data, highlighting discrepancies and biases in their predictions.

The stereochemical mechanism of the B12-dependent radical SAM glutamine methyltransferase (QCMT): Novel insights and unprecedented post-translational modifications

This study investigates the mechanism of QCMT, a B12-dependent radical SAM enzyme, revealing its unique catalytic properties and ability to perform novel post-translational modifications.

Rad52 Acts as an Assembly Chaperone to Form and Stabilize Rad51 Filaments Through a Large C-Terminus 85-Residue Segment

This study identifies an 85-residue segment of Rad52 that facilitates Rad51 filament formation and stability through structural and functional analyses in yeast.

A versatile bacterial innate immunity protein directly senses two disparate phage proteins

This study shows that the bacterial immunity protein CapRelSJ46 can sense two distinct phage proteins using the same domain, highlighting its versatility in anti-phage defense.

Molecular interactions of PCSK9 with an inhibitory nanobody, CAP1 and HLA-C: functional regulation of LDLR levels

This study determines the 3D structure of the PCSK9-CHRD-P1.40 complex and shows how CAP1 and HLA-C interact with PCSK9 to regulate LDLR degradation.