Molecular BiologyGenes & DevelopmentPeer-reviewed
Cleavage of the RNA polymerase II general transcription factor TFIIB tunes transcription during stress
Leah Gulyas, Azra Lari, Sahil B. Shah, Britt A. Glaunsinger
The paper shows that stress-induced cleavage of TFIIB by caspases-3 and 7 reduces its ability to form promoter complexes, restricting expression of stimulus-responsive genes during stress.
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