Azra Lari

Promoter-associated RNA polymerase III shapes RNA polymerase II-dependent inflammatory gene expression during viral infection

Pol III occupies TATA-enriched, TBP-dependent inflammatory gene promoters, primes basal expression, then restrains Pol II induction during MHV68, HSV-1 and influenza A infection.

Cleavage of the RNA polymerase II general transcription factor TFIIB tunes transcription during stress

The paper shows that stress-induced cleavage of TFIIB by caspases-3 and 7 reduces its ability to form promoter complexes, restricting expression of stimulus-responsive genes during stress.

Cytoplasmic mRNA decay by the anti-viral nuclease RNase L promotes transcriptional repression

This study shows that RNase L, an antiviral nuclease, represses transcription by reducing RNA polymerase II elongation, particularly affecting immune-related genes.

The SP140-RESIST pathway regulates interferon mRNA stability and antiviral immunity

This study identifies SP140's role in regulating IFN-β mRNA stability through RESIST, revealing a dual antiviral and interferon regulatory function.

RNA polymerase III transcription-associated polyadenylation promotes the accumulation of noncoding retrotransposons during infection

The paper identifies polyadenylation as a mechanism driving SINE RNA accumulation during gammaherpesvirus infection, linking Pol III transcription to mRNA-like processing.