Engineered Flt3L Drives Tolerogenic State to Attenuate Anti-drug Antibody Responses
Aaron T. Alpar, Rachel P. Wallace, Kirsten C. Refvik, Suzana Gomes, Ani Solanki, Laura T. Gray, Anna J. Slezak, Abigail L. Lauterbach, Lauren A. Hesser, Shijie Cao, Jorge Emiliano Gomez Medellin, Lauren G. Robinson, Jeffrey A. Hubbell
The paper describes a method using engineered Flt3L to induce a tolerogenic immune state, reducing anti-drug antibodies to a fungal enzyme.
bioRxiv · Mar 21, 2024 · PreprintBioengineering