Author

Shijie Cao

University of WashingtonORCID 0000-0002-9175-0813Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Aaron T. AlpariD· 1 shared Abigail L. LauterbachiD· 1 shared Ani SolankiiD· 1 shared Anna J. SlezakiD· 1 shared Brad Cleveland· 1 shared Chang LiuiD· 1 shared Changyu WangiD· 1 shared Dinh Chuong NguyeniD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperBioengineering

Aaron T. AlparORCID

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3 papers

Recent·Most cited

Indole-3-propionic acid nano-prodrugs sustain increased lymphoid exposure and alleviate experimental autoimmune arthritis

Yitong Guo, Huiqi Wang, Brad Cleveland, Ho Yeung Leung, Dinh Chuong Nguyen, Jack Thomson Smith, J. Emiliano Gomez Medellin, Giulia Elayna Stewart, Raul Johnson, Lindsey M. Williams, Xiaoxing Wang, Peng Qiu, Tomas Mustelin, Shijie Cao

This study develops and tests nano-prodrugs of indole-3-propionic acid (IPA) to treat experimental autoimmune arthritis, showing improved lymphoid exposure and immunomodulatory effects.

bioRxiv · Oct 16, 2026 · PreprintBioengineering

Berberrubine Inhibits Helicobacter pylori by Inducing Oxidative Stress

Min-Zhi Jiang, Changyu Wang, Kai Wang, Yu Yan Jiang, Xue Wang, Xinchi Feng, Shijie Cao, Liqin Ding, Shuangyu Bi, Feng Qiu, Shuang‐Jiang Liu, Chang Liu

This study identifies berberrubine as an antibacterial agent that inhibits Helicobacter pylori and Escherichia coli by inducing oxidative stress and disrupting cell membrane integrity.

bioRxiv · Mar 6, 2025 · PreprintMicrobiology

Engineered Flt3L Drives Tolerogenic State to Attenuate Anti-drug Antibody Responses

Aaron T. Alpar, Rachel P. Wallace, Kirsten C. Refvik, Suzana Gomes, Ani Solanki, Laura T. Gray, Anna J. Slezak, Abigail L. Lauterbach, Lauren A. Hesser, Shijie Cao, Jorge Emiliano Gomez Medellin, Lauren G. Robinson, Jeffrey A. Hubbell

The paper describes a method using engineered Flt3L to induce a tolerogenic immune state, reducing anti-drug antibodies to a fungal enzyme.

bioRxiv · Mar 21, 2024 · PreprintBioengineering