BiochemistryJournal of Biological ChemistryPeer-reviewed
End-product inhibition of the LRRK2-counteracting PPM1H phosphatase
Ayan Adhikari, Aashutosh Tripathi, Claire Y Chiang…·Suzanne R. Pfeffer
This study identifies an allosteric site on PPM1H phosphatase that binds non-phosphorylated Rab8A and Rab10, inhibiting its activity and regulating LRRK2 substrate dephosphorylation.