Ayan Adhikari

End-product inhibition of the LRRK2-counteracting PPM1H phosphatase

This study identifies an allosteric site on PPM1H phosphatase that binds non-phosphorylated Rab8A and Rab10, inhibiting its activity and regulating LRRK2 substrate dephosphorylation.

Lysosomal Glucocerebrosidase is needed for ciliary Hedgehog signaling: A convergent pathway to Parkinsons disease

This paper shows that mutations in LRRK2 and GBA1 impair Hedgehog signaling in the striatum through distinct mechanisms, contributing to Parkinson's disease pathogenesis.

PPM1M, a LRRK2-counteracting, phosphoRab12-preferring phosphatase with potential link to Parkinsons disease

The paper identifies PPM1M as a phosphatase that reverses LRRK2-mediated Rab phosphorylation and links a rare mutation to Parkinson's disease.