Priyanka Nandakumar

Step change in glaucoma polygenic risk score performance enables clinical utility and disease prediction across all major ancestries

This paper develops a polygenic risk score for glaucoma with improved performance across major ancestries, enabling earlier detection and targeted treatment of high-risk individuals.

Association between polygenic risk and survival in breast cancer patients

This study finds that higher polygenic risk scores for breast cancer are associated with longer survival in patients, suggesting a link between genetic predisposition and less aggressive tumors.

Insights into Ancestral Diversity in Parkinsons Disease Risk: A Comparative Assessment of Polygenic Risk Scores

This study compares polygenic risk scores for Parkinson's disease across seven ancestries, finding varying predictive accuracy and highlighting the need for ancestry-specific models.

The genetic architecture of gene expression in individuals of African and European ancestry

This study compares eQTL discovery in African and European ancestry cohorts, finding more eQTLs in African samples and improved GWAS variant-to-gene mapping using African eQTLs.

Bidirectional relationship between olfaction and Parkinson's disease

This study identifies genetic correlations between hyposmia and Parkinson's disease, finding a strong causal link from PD to hyposmia but weaker evidence for the reverse.

The shared genetic architecture and evolution of human language and musical rhythm

This study investigates the shared genetic architecture between rhythm and dyslexia using large-scale genome-wide association studies.

Multi-ancestry GWAS of Long COVID identifiesimmune-related loci and etiological links to chronic fatigue syndrome, fibromyalgia and depression

This study performs a multi-ancestry GWAS of Long COVID, identifying immune-related loci and genetic links to chronic fatigue syndrome, fibromyalgia, and depression.

Multi-ancestry GWAS of diarrhea during acute SARS-CoV2 infection identifies multiple novel loci and contrasting etiological roles of irritable bowel syndrome subtypes

This study performs a multi-ancestry GWAS of diarrhea during acute SARS-CoV2 infection, identifying six novel loci and contrasting genetic roles of IBS subtypes in COVID-19 diarrhea.

MUSSEL: Enhanced Bayesian Polygenic Risk Prediction Leveraging Information across Multiple Ancestry Groups

MUSSEL improves polygenic risk prediction across populations by integrating GWAS summary statistics and using Bayesian hierarchical modeling with ensemble learning.

Trans-ancestral Genome Wide Association Study of Sporadic and Recurrent Miscarriage

This study conducts a trans-ancestral GWAS of sporadic and recurrent miscarriage, identifying novel genetic associations and providing causal evidence for smoking and caffeine consumption.

Multi-ancestry genome-wide meta-analysis in Parkinson's disease

This paper conducts a multi-ancestry genome-wide meta-analysis of Parkinson's disease, identifying 78 independent loci and 23 genes associated with PD risk.

A new method for multi-ancestry polygenic prediction improves performance across diverse populations

The paper introduces CT-SLEB, a method for multi-ancestry polygenic prediction that improves performance in non-European populations using GWAS summary statistics and simulation studies.

Discovery of genomic loci associated with sleep apnoea risk through multi-trait GWAS analysis with snoring

This study identifies 49 genetic loci associated with sleep apnoea risk using multi-trait GWAS, with 29 replicated in a large cohort, and finds genetic correlations with several complex traits.

Genome-wide association study of musical beat synchronization demonstrates high polygenicity

This study conducts a genome-wide association study to identify genetic variants linked to musical beat synchronization, finding high polygenicity with 69 significant loci and heritability estimates of 13%-16%.

Genetic analyses identify widespread sex-differential participation bias

The paper identifies sex-differential participation bias in genetic studies by performing GWAS on sex in 3.3 million individuals, finding 158 loci associated with sex and highlighting traits like BMI that may influence participation.

Genetic determinants of daytime napping and effects on cardiometabolic health

This study identifies genetic loci associated with daytime napping and finds potential causal links between napping and cardiometabolic traits.

Genome-wide study identifies association between HLA-B*55:01 and penicillin allergy

The paper identifies HLA-B*55:01 as a genetic risk factor for penicillin allergy through genome-wide analysis of electronic health records and imputed HLA data.

Analysis of putative cis-regulatory elements regulating blood pressure variation

The paper identifies putative cis-regulatory elements associated with blood pressure traits using open chromatin and gene expression data, and identifies several candidate genes for further functional testing.

Genome-wide association and multi-omic analyses reveal new mechanisms for Heart Failure

This study identifies one known and two novel genetic variants associated with heart failure through GWAS and multi-omic analyses, revealing potential causal mechanisms and shared heritability with musculoskeletal traits.

Insight into the genetic aetiology of retinal detachment by combining small clinical and large population-based datasets

This study identifies 11 genome-wide significant loci for retinal detachment by combining small clinical and large population-based datasets, with six loci replicated in an independent dataset.