This study investigates genetic factors influencing weight loss from GLP1-RA and bariatric surgery in 10,960 individuals across 9 biobanks, finding no strong genetic associations with GLP1-RA effectiveness but a modest link between BMI polygenic scores and reduced bariatric surgery weight loss.

medRxiv · Sep 11, 2024 · PreprintGenetic & Genomic Medicine

Genetic risk factors have a substantial impact on healthy life years

Sakari Jukarainen, Tuomo Kiiskinen, Sara Kuitunen, Aki Samuli Havulinna, Juha M Karjalainen, Mattia Cordioli, Joel T Rämö, Nina Mars, FinnGen, Kaitlin E. Samocha, Hanna Maria Ollila, Matti Pirinen, Andrea Ganna

This study estimates the impact of genetic risk factors on disease burden using disability-adjusted life years (DALYs) and finds that both common and rare variants significantly contribute to healthy life years lost.

Nature Medicine · Sep 1, 2022Peer-reviewedGenetic & Genomic Medicine

Mapping the human genetic architecture of COVID-19: an update

COVID-19 Host Genetics Initiative, Leadership, Gita A. Pathak, Juha M Karjalainen, Christine R. Stevens, Benjamin M. Neale, Mark J. Daly, Andrea Ganna, Writing group, Writing group lead, Shea J. Andrews, Masahiro Kanai, Mattia Cordioli, Analysis group, Manuscript analyses team lead, , David Morrison

This study updates the genetic architecture of COVID-19 by adding 11 new genome-wide significant loci through a large GWAS meta-analysis.

Nature · Aug 3, 2022Peer-reviewedGenetic & Genomic Medicine

Patterns of item nonresponse behavior to survey questionnaires are systematic and have a genetic basis

Gianmarco Mignogna, Caitlin E. Carey, Robbee Wedow, Nikolas A. Baya, Mattia Cordioli, Nicola Pirastu, Rino Bellocco, Michel Guillaume Nivard, Benjamin M. Neale, Raymond Kenney Walters, Andrea Ganna

The paper identifies genetic loci associated with survey nonresponse behaviors and shows their genetic correlation with education and health.

bioRxiv · Feb 11, 2022 · PreprintGenetics

Insights into genetic factors contributing to variability in SARS-CoV-2 susceptibility and COVID-19 disease severity

Matteo D’Antonio, Jennifer Nguyen, Timothy D. Arthur, Hiroko Matsui, Agnieszka D’Antonio‐Chronowska, Kelly A. Frazer, Benjamin M. Neale, Mark J. Daly, Andrea Ganna, Christine R. Stevens, G. K. Pathak, Shea J. Andrews, Masahiro Kanai, Mattia Cordioli, Juha M Karjalainen, , Rasoul Aliannejad

This study identifies genetic loci associated with SARS-CoV-2 susceptibility and disease severity using GWAS and colocalization, and links them to eQTLs in various tissues.

Cell Reports · Nov 1, 2021Peer-reviewedGenetic & Genomic Medicine

Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality

Tomoko Nakanishi, Sara Pigazzini, Frauke Degenhardt, Mattia Cordioli, Guillaume Butler‐Laporte, Douglas Maya‐Miles, Beatriz Nafría Jiménez, Youssef Bouysran, Mari Niemi, Adriana Palom, David Ellinghaus, Atlas Khan, Manuel Martínez‐Bueno, Selina Rolker, Sara Amitano, , Andrea Ganna

This study examines how a major genetic risk factor for COVID-19 affects mortality and severity, finding stronger effects in younger adults.

Journal of Clinical Investigation · Oct 1, 2021Peer-reviewedGenetic & Genomic Medicine

Genetic analyses identify widespread sex-differential participation bias

Nicola Pirastu, Mattia Cordioli, Priyanka Nandakumar, Gianmarco Mignogna, Abdel Abdellaoui, Benjamin Hollis, Masahiro Kanai, Veera Manikandan Rajagopal, Pietro Della Briotta Parolo, Nikolas A. Baya, Caitlin E. Carey, Juha M Karjalainen, Thomas D. Als, Matthijs D. van der Zee, Felix R. Day, , Andrea Ganna

The paper identifies sex-differential participation bias in genetic studies by performing GWAS on sex in 3.3 million individuals, finding 158 loci associated with sex and highlighting traits like BMI that may influence participation.

Nature Genetics · Apr 22, 2021Peer-reviewedGenetics

Mapping the human genetic architecture of COVID-19 by worldwide meta-analysis

Mari Niemi, Juha M Karjalainen, Rachel G. Liao, Benjamin M. Neale, Mark J. Daly, Ganna Andrea, Gita A. Pathak, Shea J. Andrews, Kanai Masahiro, Kumar Veerapen, Israel Fernández‐Cadenas, Eva C. Schulte, Pasquale Striano, Minttu Marttila, Camelia Minica, , Bahareh Sedaghati-khayat

This study identifies 13 genome-wide significant loci associated with SARS-CoV-2 infection or severe COVID-19 through a global meta-analysis of 49,562 patients.

Research at the University of Copenhagen (University of Copenhagen) · Jan 1, 2021Peer-reviewedGenetic & Genomic Medicine

Findings and insights from the genetic investigation of age of first reported occurrence for complex disorders in the UK Biobank and FinnGen

Yen‐Chen Anne Feng, Tian Ge, Mattia Cordioli, FinnGen, Andrea Ganna, Jordan W. Smoller, Benjamin M. Neale

The paper investigates the heritability of age of first occurrence for complex disorders using GWAS data from UK Biobank and FinnGen, finding genetic contributions and correlations with disease susceptibility.

medRxiv · Nov 20, 2020 · PreprintGenetic & Genomic Medicine