Cell-autonomous immune dysfunction driven by disrupted autophagy in C9orf72-ALS iPSC-derived microglia contributes to neurodegeneration
Poulomi Banerjee, Arpan R. Mehta, Raja Sekhar Nirujogi, James D. Cooper, Owen G. James, Jyoti Nanda, James Longden, Karen Burr, Karina McDade, Andrea Salzinger, Evdokia Paza, Judith Lowder Newton, David Story, Suvankar Pal, Colin Smith, , Siddharthan Chandran
This study shows that C9orf72 mutations disrupt autophagy in microglia, leading to immune dysfunction and increased motor neuron death in ALS/FTD.
Science Advances · Apr 21, 2023Peer-reviewedNeuroscience