Author

Andrea Salzinger

UK Dementia Research InstituteORCID 0000-0002-8100-8236Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:imaging· 1 Research Focus:spatial domain detection· 1 Approach:statistical model· 1

Frequent Co-Authors

Aaron HeldiD· 1 shared Alberto CataneseiD· 1 shared Andreas HermanniD· 1 shared Annekathrin Rödiger· 1 shared Anže Karlek· 1 shared Arpan R. MehtaiD· 1 shared Banaja P. DashiD· 1 shared Bhuvaneish Thangaraj SelvarajiD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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1 shared paperNeuroscience

Aaron HeldORCID

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3 papers

Recent·Most cited

RIG-I mediated neuron-specific IFN type 1 signaling in FUS-ALS induces neurodegeneration and offers new biomarker-driven individualized treatment options for (FUS-)ALS

Marcel Naumann, Theresa M. Wierschin, Stefanie Kretschmer, Banaja P. Dash, Aaron Held, Andrea Salzinger, Kevin Peikert, Anže Karlek, Hannes Glaß, Dajana Großmann, René Günther, Susanne Petri, Annekathrin Rödiger, Dávid Brenner, Francisco J. Pan-Montojo, , Andreas Hermann

The paper identifies RIG-I-mediated innate immune activation in FUS-ALS spinal motor neurons due to mitochondrial dsRNA accumulation, which can be targeted by JAK-STAT inhibition, offering potential biomarker-driven treatment options.

Advanced Science · Jan 28, 2026Peer-reviewedNeuroscience

C9ORF72 deficiency results in degeneration of the zebrafish retina in vivo

Natalia Jaroszynska, Andrea Salzinger, Themistoklis M. Tsarouchas, Catherina Gwynne Becker, Thomas Becker, David Anthony Lyons, Ryan B. MacDonald, Marcus Keatinge

This study shows that C9ORF72 deficiency in zebrafish causes retinal degeneration, including reduced thickness, gliosis, and neuronal loss, but not spinal cord pathology.

bioRxiv · Oct 19, 2023 · PreprintNeuroscience

Cell-autonomous immune dysfunction driven by disrupted autophagy in C9orf72-ALS iPSC-derived microglia contributes to neurodegeneration

Poulomi Banerjee, Arpan R. Mehta, Raja Sekhar Nirujogi, James D. Cooper, Owen G. James, Jyoti Nanda, James Longden, Karen Burr, Karina McDade, Andrea Salzinger, Evdokia Paza, Judith Lowder Newton, David Story, Suvankar Pal, Colin Smith, , Siddharthan Chandran

This study shows that C9orf72 mutations disrupt autophagy in microglia, leading to immune dysfunction and increased motor neuron death in ALS/FTD.

Science Advances · Apr 21, 2023Peer-reviewedNeuroscience