Author

Owen G. James

UK Dementia Research InstituteORCID 0000-0001-9948-2190Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 1 Organism:zebrafish· 1

Frequent Co-Authors

Siddharthan ChandraniD· 2 shared Andrea SalzingeriD· 1 shared Anna WilliamsiD· 1 shared Arpan R. MehtaiD· 1 shared Bhuvaneish Thangaraj SelvarajiD· 1 shared Cody L. CalliD· 1 shared Colin SmithiD· 1 shared Dario R. AlessiiD· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersNeuroscience

Siddharthan ChandranORCID

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2 papers

Recent·Most cited

NeuroscienceScience AdvancesPeer-reviewedApr 21, 2023

Cell-autonomous immune dysfunction driven by disrupted autophagy in C9orf72-ALS iPSC-derived microglia contributes to neurodegeneration

Poulomi Banerjee, Arpan R. Mehta, Raja Sekhar Nirujogi…·Siddharthan Chandran

This study shows that C9orf72 mutations disrupt autophagy in microglia, leading to immune dysfunction and increased motor neuron death in ALS/FTD.

54 citationstop 1%

humanexperimental assay

NeurosciencebioRxivPreprintFeb 16, 2022

Oligodendrocytes form paranodal bridges that generate chains of myelin sheaths vulnerable to degeneration with age

Cody L. Call, Sarah A. Neely, Jason J. Early…·Dwight E. Bergles

The paper identifies a conserved myelination mechanism in oligodendrocytes that forms paranodal bridges, enabling extended myelin sheaths along axons, which degenerate more frequently with age.

5 citations