Hossein Jashnsaz

TrueSpot: A robust automated tool for quantifying signal puncta in fluorescent imaging

TrueSpot is an automated tool for quantifying signal puncta in fluorescent imaging, outperforming 2D methods in 3D spot detection.

Phenotypic consequences of logarithmic signaling in MAPK stress response

The paper investigates how dynamic stress gradients affect cell growth and signaling in yeast, finding that gradual stress enhances growth with minimal volume reduction through a logarithmic MAPK signaling mechanism.

A rate threshold mechanism regulates MAPK stress signaling and survival

The paper shows that stimulation rate, along with concentration, determines MAPK signaling and cell survival in budding yeast through a rate threshold mechanism.

Diverse cell stimulation kinetics identify predictive signal transduction models

The paper uses live single-cell imaging and computational modeling to show that diverse kinetic stimulations improve prediction of signaling dynamics by better constraining model parameters.

Generating kinetic environments to study dynamic cellular processes in single cells

The paper develops experimental methodologies to control temporal changes in extracellular stimuli for studying dynamic cellular processes in single cells.