Author

Alexander Thiemicke

Vanderbilt UniversityORCID 0000-0002-9822-1017Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:yeast· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:deep learning· 1

Frequent Co-Authors

Gregor NeuertiD· 4 shared Guoliang LiiD· 3 shared Benjamin K. Kesler· 2 shared Hossein JashnsaziD· 2 shared Amanda N. JohnsoniD· 1 shared Dustin C. Rogers· 1 shared Rohit Venkat· 1 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 18 mutual co-author links

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4 shared papersSystems Biology

Gregor NeuertORCID

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4 papers

Recent·Most cited

A rate threshold mechanism regulates MAPK stress signaling and survival

Amanda N. Johnson, Guoliang Li, Hossein Jashnsaz, Alexander Thiemicke, Benjamin K. Kesler, Dustin C. Rogers, Gregor Neuert

The paper shows that stimulation rate, along with concentration, determines MAPK signaling and cell survival in budding yeast through a rate threshold mechanism.

Proceedings of the National Academy of Sciences · Dec 21, 2020Peer-reviewedSystems Biology

Kinetics of osmotic stress regulates a cell fate switch of cell survival

Alexander Thiemicke, Gregor Neuert

The paper shows that gradual hyperosmotic stress allows human cells to survive by preventing caspase activation and accumulating proline, unlike acute stress.

bioRxiv · Jul 10, 2020Cell Biology

Automated cell boundary and 3D nuclear segmentation of cells in suspension

Benjamin K. Kesler, Guoliang Li, Alexander Thiemicke, Rohit Venkat, Gregor Neuert

The paper introduces CellDissect, a method for automated cell and nuclear segmentation in suspension cells using widefield images, and evaluates its accuracy against manual segmentation.

Scientific Reports · Jul 15, 2019Peer-reviewedSystems Biology

Generating kinetic environments to study dynamic cellular processes in single cells

Alexander Thiemicke, Hossein Jashnsaz, Guoliang Li, Gregor Neuert

The paper develops experimental methodologies to control temporal changes in extracellular stimuli for studying dynamic cellular processes in single cells.

Scientific Reports · Jul 12, 2019Peer-reviewedSystems Biology