Deficiency of MicroRNA-181a Results in Transcriptome-Wide Cell Specific Changes in the Kidney that Lead to Elevated Blood Pressure and Salt Sensitivity
Madeleine R. Paterson, Kristy L. Jackson, Malathi S.I. Dona, Gabriella E. Farrugia, Bruna Visniauskas, Anna M.D. Watson, Chad J Johnson, Minolfa C. Prieto, Roger G. Evans, Fadi Joseph Charchar, Alexander Ruvantha Pinto, Francine Z. Marques, Geoffrey A. Head
This study shows that miR-181a deficiency in mice leads to elevated blood pressure and salt sensitivity through increased renin expression and widespread renal gene dysregulation.
Hypertension · Sep 20, 2021Peer-reviewedGenomics