Francine Z. Marques

The paper identifies rare pathogenic variants in GPCR genes linked to gut-to-host communication and finds they are associated with increased cardiovascular disease risk in humans.

This study shows that dietary fibre and SCFA supplementation improve post-stroke outcomes in mice by modulating the gut microbiome and acting through GPR41/43/109A receptors.

The paper shows that gut bacteria translocate to the brain after stroke via the sympathetic nervous system, worsening motor function in mice.

This study shows dietary fiber lowers blood pressure by reducing large intestinal pH and activating GPR65 in CD8+ T cells, which reduces inflammation and hypertension-related damage.

This study shows that miR-181a deficiency in mice leads to elevated blood pressure and salt sensitivity through increased renin expression and widespread renal gene dysregulation.