Gabriella E. Farrugia

This study identifies autoimmune-like CD8⁺ T cell responses as drivers of atherosclerotic plaque instability and predictors of cardiovascular events in humans and mice.

This study identifies a novel fibroblast subcluster, Fibro-Cthrc1, as a driver of aortic fibrosis in hypertension using scRNA-seq and validates its association with blood pressure in humans.

This study uses single-cell multiomic analysis to identify transcriptional circuits driving non-ischemic cardiac fibrosis in mouse and human hearts, showing reversibility of fibrosis-related changes.

This study uses single-nucleus RNA sequencing to analyze adipose tissue changes in a mouse model of type-2 diabetes, revealing altered cellular phenotypes and transcriptional circuits.

This study shows that miR-181a deficiency in mice leads to elevated blood pressure and salt sensitivity through increased renin expression and widespread renal gene dysregulation.