Alexander Ruvantha Pinto

This study identifies age-acquired enhancers in mouse hearts and shows that exercise can reverse their activation.

This study identifies autoimmune-like CD8⁺ T cell responses as drivers of atherosclerotic plaque instability and predictors of cardiovascular events in humans and mice.

The paper defines the role of smooth muscle cells in ECM remodeling during human wound healing and identifies TIMP1 as a key factor in effective repair.

This study identifies sex-specific mitochondrial dysfunction in endothelial cells of diabetic PAD patients, showing that MitoQ improves vascular function in females.

The paper introduces APAS, a method to generate environmentally relevant micro- and nanoplastics by simulating natural aging processes, and shows its ability to produce complex particles with physicochemical properties similar to real-world MNPs.

This study identifies a novel fibroblast subcluster, Fibro-Cthrc1, as a driver of aortic fibrosis in hypertension using scRNA-seq and validates its association with blood pressure in humans.

This study uses single-cell multiomic analysis to identify transcriptional circuits driving non-ischemic cardiac fibrosis in mouse and human hearts, showing reversibility of fibrosis-related changes.

This study uses single-nucleus RNA sequencing to analyze adipose tissue changes in a mouse model of type-2 diabetes, revealing altered cellular phenotypes and transcriptional circuits.

This study shows that miR-181a deficiency in mice leads to elevated blood pressure and salt sensitivity through increased renin expression and widespread renal gene dysregulation.