A modular model integrating metabolism, growth, and cell cycle predicts that fermentation is required to modulate cell size in yeast populations
Marco Vanoni, Pasquale J Palumbo, Federico Papa, Stefano Busti, Laura Gotti, Meike Tessa Wortel, Bas Teusink, Ivan Orlandi, Alex Pessina, Cristina Airoldi, Luca Brambilla, Marina Vai, Lilia Alberghina
The paper develops a multiscale computational model integrating metabolism, growth, and cell cycle in yeast to predict that fermentation modulates cell size under different growth conditions.
PLoS Computational Biology · Jul 21, 2025Peer-reviewedSystems Biology