Upstream alternative polyadenylation in SCN5A produces a short transcript isoform encoding a mitochondria-localized NaV1.5 N-terminal fragment that influences cardiomyocyte respiration
Nathan H. Witmer, Jared M. McLendon, Colleen S. Stein, Jin‐Young Yoon, Elena V. Berezhnaya, John W. Elrod, Barry London, Ryan L. Boudreau
This study identifies an upstream alternative polyadenylation event in SCN5A that generates a short transcript encoding a mitochondria-localized NaV1.5 N-terminal fragment, which affects cardiomyocyte respiration.
bioRxiv · Aug 9, 2024 · PreprintPhysiology