Barry London

This study examines the chronic cardiovascular effects of daunorubicin in Ts65Dn mice, a model of Down syndrome, compared to wild-type mice, finding strain-specific differences in cardiac and vascular function.

This study identifies chamber-specific contributions of non-NaV1.5 sodium channel isoforms to cardiac excitability using a chemical-genetic mouse model and electrophysiological recordings.

The paper identifies cardiac-specific RNA aptamers that selectively target and internalize into ventricular cardiomyocytes in vivo.

This study identifies an upstream alternative polyadenylation event in SCN5A that generates a short transcript encoding a mitochondria-localized NaV1.5 N-terminal fragment, which affects cardiomyocyte respiration.

This study identifies 210 genetic loci associated with the PR interval through multi-ancestry GWAS, highlighting their role in cardiac conduction and cardiovascular disease.

This study conducts a large GWAS on heart failure, identifying 12 genetic loci with associations to CAD, atrial fibrillation, and reduced left ventricular function, and provides causal evidence for several risk factors.