Author

Jared M. McLendon

University of IowaORCID 0000-0002-1002-5872Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Organism:C. elegans· 1

Frequent Co-Authors

Ryan L. BoudreauiD· 3 shared Barry LondoniD· 2 shared Jin‐Young YooniD· 2 shared Abigail Burrows-Franco· 1 shared Ahmed IsmaeeliD· 1 shared Alex DouiD· 1 shared Alyssa R. Daniel· 1 shared Bailey D. Peck· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersPhysiology

Ryan L. BoudreauORCID

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Author profile →

4 papers

Recent·Most cited

Sub-Chronic Chlorpyrifos Exposure Leads to Epigenetic and Sex-Specific Behavioral Changes in Adult Mice

Alyssa R. Daniel, Noah Gernander, Sara Dodge, Cessily Hayes, Emma Simpson-Wade, Emese H. C. Kovács, Gibson Dowd, Jared M. McLendon, Benjamin Wen Qing Hing, Marie E. Gaine

This study shows that sub-chronic chlorpyrifos exposure causes sex-specific behavioral and epigenetic changes in adult mice, with female-specific effects independent of AChE activity and DNA methylation.

bioRxiv · Jun 11, 2026 · PreprintNeuroscience

Non-canonical Sodium Channel Isoforms Underlie Chamber Specific Cardiac Excitability

Colin J. Clark, Christian Anderson, Alex Dou, Jason M. Dierdorff, Jason D. Galpin, Lionel Gissot, Samantha L. Thompson, Hannah Choi, Jin‐Young Yoon, Daniel T. Infield, Jared M. McLendon, Peter Bronk, Keane Leeds, Ryan L. Boudreau, Bum‐Rak Choi, , Christopher A. Ahern

This study identifies chamber-specific contributions of non-NaV1.5 sodium channel isoforms to cardiac excitability using a chemical-genetic mouse model and electrophysiological recordings.

bioRxiv · Aug 27, 2025 · PreprintPhysiology

microRNA-1 Regulates Metabolic Flexibility in Skeletal Muscle via Pyruvate Metabolism

Ahmed Ismaeel, Bailey D. Peck, McLane M. Montgomery, Benjamin I. Burke, Jensen Z. Goh, Gyumin Kang, Abigail Burrows-Franco, Qin Xia, Katarzyna Goljanek‐Whysall, Brian McDonagh, Jared M. McLendon, Pieter Jan Koopmans, Daniel Jacko, Kirill Schaaf, Wilhelm Bloch, , John Joseph McCarthy

This study shows miR-1 regulates metabolic flexibility in skeletal muscle by controlling pyruvate metabolism, with loss of miR-1 causing metabolic inflexibility and reduced endurance.

Molecular Metabolism · Jun 7, 2025Peer-reviewedPhysiology

Upstream alternative polyadenylation in SCN5A produces a short transcript isoform encoding a mitochondria-localized NaV1.5 N-terminal fragment that influences cardiomyocyte respiration

Nathan H. Witmer, Jared M. McLendon, Colleen S. Stein, Jin‐Young Yoon, Elena V. Berezhnaya, John W. Elrod, Barry London, Ryan L. Boudreau

This study identifies an upstream alternative polyadenylation event in SCN5A that generates a short transcript encoding a mitochondria-localized NaV1.5 N-terminal fragment, which affects cardiomyocyte respiration.

bioRxiv · Aug 9, 2024 · PreprintPhysiology