The Leiden ex vivo human growth plate model in severe tall stature: a proof-of-concept study
Margo Tuerlings, Y.F. Ramos, H. Eka D. Suchiman, Sayedeh Sana Sayedipour, Sjoerd D. Joustra, Anika Rabelink-Hoogenstraaten, Hermine A. van Duyvenvoorde, Dagmar R. J. Kempink, Pieter Bas de Witte, Ingrid Meulenbelt, Christiaan de Bruin
This study demonstrates the feasibility of establishing an ex vivo human growth plate model using tissue from percutaneous epiphysiodesis procedures to study bone growth and pediatric growth disorders.
bioRxiv · Sep 11, 2026 · PreprintDevelopmental Biology