Sayedeh Sana Sayedipour

The Leiden ex vivo human growth plate model in severe tall stature: a proof-of-concept study

This study demonstrates the feasibility of establishing an ex vivo human growth plate model using tissue from percutaneous epiphysiodesis procedures to study bone growth and pediatric growth disorders.

Spatial transcriptomics defines the mechanisms of hiPSC derived stem cell mediated repair in human articular cartilage

The paper evaluates the therapeutic effects of hiMSCs in osteoarthritis models, showing reduced damage and activation of cholesterol pathways, with spatial transcriptomics revealing localized molecular changes.

Dynamic suspension culture enhances scalable maturation of hiPSC-derived cartilage organoids for regenerative medicine

This paper develops a dynamic suspension culture system to improve the maturation of hiPSC-derived cartilage organoids, showing enhanced ECM deposition and gene expression compared to static culture.

Evaluating the Therapeutic Efficacy of Iopanoic Acid in a DMM-Induced Osteoarthritis Mouse Model and Osteochondral Lesioned Human Explants

This study evaluates iopanoic acid's therapeutic effects on osteoarthritis using mouse models and human tissue explants, showing reduced cartilage degradation and improved repair.

Therapeutic efficacy of hiMSC-derived Extracellular Vesicles from Serum-containing and Xeno-free media for osteoarthritis treatment

This study evaluates the therapeutic effects of hiEVs from different media in an OA mouse model, finding that xeno-free hiEVs reduce joint damage and promote cartilage repair.

Advancing Therapeutic Solutions: Poloxamer-based Thermosensitive Injectable Hydrogels containing a Self-assembling Peptide for In situ Gelation in an Osteoarthritis Murine Model

This paper develops a poloxamer-based hydrogel with a self-assembling peptide for rapid in situ gelation and sustained drug delivery in an osteoarthritis mouse model.