Ingrid Meulenbelt

This study demonstrates the feasibility of establishing an ex vivo human growth plate model using tissue from percutaneous epiphysiodesis procedures to study bone growth and pediatric growth disorders.

The paper evaluates the therapeutic effects of hiMSCs in osteoarthritis models, showing reduced damage and activation of cholesterol pathways, with spatial transcriptomics revealing localized molecular changes.

This paper develops a dynamic suspension culture system to improve the maturation of hiPSC-derived cartilage organoids, showing enhanced ECM deposition and gene expression compared to static culture.

This study evaluates iopanoic acid's therapeutic effects on osteoarthritis using mouse models and human tissue explants, showing reduced cartilage degradation and improved repair.

The paper maps chondrogenic cell-fate trajectories in hiPSCs using scRNA-seq and scATAC-seq, identifying NFIA and NFIB as key regulators driving chondrogenic commitment.

This study shows that cell culture dimensionality affects intracellular crowding, which influences cell fate through a mechano-metabolic signaling pathway, improving chondrogenic differentiation in microtissue cultures.

This study evaluates the therapeutic effects of hiEVs from different media in an OA mouse model, finding that xeno-free hiEVs reduce joint damage and promote cartilage repair.

This paper develops a poloxamer-based hydrogel with a self-assembling peptide for rapid in situ gelation and sustained drug delivery in an osteoarthritis mouse model.

This paper investigates how a COL6A3 mutation affects chondrocyte response to mechanical stress in a human iPSC-derived cartilage organoid model, finding reduced PCM protein binding and impaired stress response.

The paper identifies transcript SNPs with allelic expression imbalance in OA risk loci from articular cartilage and subchondral bone, revealing new potential OA risk genes.

This study uses multivariable Mendelian randomization to show that higher bone mineral density causally increases osteoarthritis risk independently of body mass index.

The paper identifies differentially expressed genes in OA subchondral bone and cartilage using RNA sequencing, highlighting IL11 and CHADL as potential druggable targets.

The paper identifies differentially expressed lncRNAs in OA cartilage and validates their regulatory role on adjacent genes.

The paper identifies 49 genes and pathways associated with osteoarthritis progression using integrative epigenomics, transcriptomics, and proteomics in human chondrocytes from OA patients.