This study demonstrates the feasibility of establishing an ex vivo human growth plate model using tissue from percutaneous epiphysiodesis procedures to study bone growth and pediatric growth disorders.

bioRxiv · Sep 11, 2026 · PreprintDevelopmental Biology

Spatial transcriptomics defines the mechanisms of hiPSC derived stem cell mediated repair in human articular cartilage

Y.F. Ramos, Sayedeh Sana Sayedipour, Georgina Shaw, Margo Tuerlings, Timo Schomann, H. Eka D. Suchiman, Davy Cats, Frank Barry, Rachid Mahdad, Hailiang Mei, Luis Javier Cruz, Mary Murphy, Ingrid Meulenbelt

The paper evaluates the therapeutic effects of hiMSCs in osteoarthritis models, showing reduced damage and activation of cholesterol pathways, with spatial transcriptomics revealing localized molecular changes.

bioRxiv · Jul 23, 2026 · PreprintDevelopmental Biology

Evaluating the Therapeutic Efficacy of Iopanoic Acid in a DMM-Induced Osteoarthritis Mouse Model and Osteochondral Lesioned Human Explants

Sayedeh Sana Sayedipour, Giorgia Mazzini, Margo Tuerlings, Jelle Nikkels, Marijke Koedam, Luis Javier Cruz, Rachid Mahdad, Louise van der Weerd, Bram C. J. van der Eerden, Y.F. Ramos, Ingrid Meulenbelt

This study evaluates iopanoic acid's therapeutic effects on osteoarthritis using mouse models and human tissue explants, showing reduced cartilage degradation and improved repair.

Osteoarthritis and Cartilage Open · Jun 5, 2026Peer-reviewedMolecular Biology

Allelic expression imbalance in articular cartilage and subchondral bone refined genome-wide association signals in osteoarthritis.

Rodrigo Coutinho de Almeida, Margo Tuerlings, Y.F. Ramos, Wouter den Hollander, H. Eka D. Suchiman, Nico Lakenberg, Rob G. H. H. Nelissen, Hailiang Mei, Ingrid Meulenbelt

The paper identifies transcript SNPs with allelic expression imbalance in OA risk loci from articular cartilage and subchondral bone, revealing new potential OA risk genes.

Lara D. Veeken · Aug 30, 2022Peer-reviewedGenetic & Genomic Medicine

Using multivariable Mendelian randomization to estimate the causal effect of bone mineral density on osteoarthritis risk, independent of body mass index

April E. Hartley, Eleanor C. M. Sanderson, Raquel Granell, Lavinia Paternoster, Jie Zheng, George Davey Smith, Lorraine Southam, Konstantinos Hatzikotoulas, Cindy Germaine Boer, Joyce B. J. van Meurs, Eleftheria Zeggini, Lilja Stefánsdóttir, Yanfei Zhang, Rodrigo Coutinho de Almeida, Tian T. Wu, , Jonathan H. Tobias

This study uses multivariable Mendelian randomization to show that higher bone mineral density causally increases osteoarthritis risk independently of body mass index.

International Journal of Epidemiology · Nov 15, 2021Peer-reviewedGenetic & Genomic Medicine

RNA sequencing reveals interacting key determinants of osteoarthritis acting in subchondral bone and articular cartilage.

Margo Tuerlings, Marcella van Hoolwerff, Evelyn Houtman, H. Eka D. Suchiman, Nico Lakenberg, Hailiang Mei, Enrike van der Linden, Rob G. H. H. Nelissen, Y.F. Ramos, Rodrigo Coutinho de Almeida, Ingrid Meulenbelt

The paper identifies differentially expressed genes in OA subchondral bone and cartilage using RNA sequencing, highlighting IL11 and CHADL as potential druggable targets.

Arthritis & Rheumatology · Dec 1, 2020Peer-reviewedGenomics

Elucidating another level of epigenetic regulation in osteoarthritis by identifying functional cis-acting long non-coding RNAs and their targets in articular cartilage

Marcella van Hoolwerff, Paula I. Metselaar, Margo Tuerlings, H. Eka D. Suchiman, Nico Lakenberg, Y.F. Ramos, Davy Cats, Rob G. H. H. Nelissen, Demiën Broekhuis, Hailiang Mei, Rodrigo Coutinho de Almeida, Ingrid Meulenbelt

The paper identifies differentially expressed lncRNAs in OA cartilage and validates their regulatory role on adjacent genes.

bioRxiv · Mar 23, 2020 · PreprintGenomics