Author

Alessia Cavazza

University of Modena and Reggio EmiliaORCID 0000-0002-4735-2121Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Adrian James ThrasheriD· 2 shared Asma NaseemiD· 2 shared Federica ZinghirinoiD· 2 shared Giandomenico TurchianoiD· 2 shared Antonio CarusilloiD· 1 shared Carlo CiprianiiD· 1 shared Daniela CesanaiD· 1 shared Eduardo Gómez‐CastañedaiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMolecular Biology

Adrian James ThrasherORCID

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2 papers

Recent·Most cited

In-Depth Characterization of Stem Cell Potency and Genotoxicity for Clinical-Scale Ex Vivo CRISPR/Cas9 Gene Editing

Asma Naseem, Winston Vetharoy, Thomas E. Whittaker, Federica Zinghirino, Antonio Carusillo, Roopkatha Ghosh, Eduardo Gómez‐Castañeda, Hashim Ali, Carlo Cipriani, Eugenio Montini, Adrian James Thrasher, Giorgia Santilli, Daniela Cesana, Giandomenico Turchiano, Alessia Cavazza

This study develops a clinical-compliant framework for ex vivo CRISPR/Cas9 gene editing of HSPCs to correct WAS, showing improved engraftment and a favorable safety profile with minimal off-target effects.

Molecular Therapy Advances · Jul 22, 2026Peer-reviewedMolecular Biology

CRISPR/Cas9-based disease modelling and functional correction of Interleukin 7 Receptor alpha Severe Combined Immunodeficiency in T-lymphocytes and hematopoietic stem cells

Rajeev Rai, Zohar Steinberg, Marianna Romito, Federica Zinghirino, Yiting Hu, Nathan White, Asma Naseem, Adrian James Thrasher, Giandomenico Turchiano, Alessia Cavazza

The paper develops a CRISPR/Cas9-based gene editing strategy to correct IL7R-SCID in T cells and HSPCs, restoring IL7R expression and T cell development.

Human Gene Therapy · Jan 22, 2024Peer-reviewedMolecular Biology