Author

Thomas E. Whittaker

UCL Biomedical Research CentreORCID 0000-0002-3181-4571Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Assay:CRISPR screen· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Adrian James ThrasheriD· 2 shared Giorgia SantilliiD· 2 shared Hashim AliiD· 2 shared A. W. Edith ChaniD· 1 shared Alessia CavazzaiD· 1 shared Antonio CarusilloiD· 1 shared Asma NaseemiD· 1 shared Aura Hare· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCell Biology

Adrian James ThrasherORCID

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2 papers

Recent·Most cited

A modified cyclosporine enhances lentivector transduction ex vivo and in vivo by degrading IFITM3

Dara Annett, Bethan J. Critchley, Kate L. Morling, Ben Graham, Valeria Pingitore, Thomas E. Whittaker, Nada Kurdi, J.M. Warne, Shefta E. Moula, Diego León‐Rico, Nihansu Kuru, Sara Toros, Tasnim Nurullah, Aura Hare, Matthew V. X. Whelan, , Greg J. Towers

BG147 enhances lentivector transduction in HSPCs ex vivo and in mouse photoreceptors in vivo by degrading IFITM3.

Molecular Therapy · Aug 3, 2026Peer-reviewedCell Biology

In-Depth Characterization of Stem Cell Potency and Genotoxicity for Clinical-Scale Ex Vivo CRISPR/Cas9 Gene Editing

Asma Naseem, Winston Vetharoy, Thomas E. Whittaker, Federica Zinghirino, Antonio Carusillo, Roopkatha Ghosh, Eduardo Gómez‐Castañeda, Hashim Ali, Carlo Cipriani, Eugenio Montini, Adrian James Thrasher, Giorgia Santilli, Daniela Cesana, Giandomenico Turchiano, Alessia Cavazza

This study develops a clinical-compliant framework for ex vivo CRISPR/Cas9 gene editing of HSPCs to correct WAS, showing improved engraftment and a favorable safety profile with minimal off-target effects.

Molecular Therapy Advances · Jul 22, 2026Peer-reviewedMolecular Biology