Genomic splice-donor disruption rescues systemic disease in progeria
Wei Zhu Jin, Jingchun Ma, Hao Yuan…·Zhongjun Zhou
This paper shows that disrupting a faulty splice donor site in progeria reduces toxic protein levels and extends lifespan in mice.
Author
University of Hong KongORCID 0000-0001-7092-8128Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
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Wei Zhu Jin, Jingchun Ma, Hao Yuan…·Zhongjun Zhou
This paper shows that disrupting a faulty splice donor site in progeria reduces toxic protein levels and extends lifespan in mice.
Rong Li, Jingchu Hu, Wei Jin…·Jian‐Dong Huang
This study shows that a single dose of Salmonella YB1 vaccine induces long-term protective trained immunity in NK cells, enhancing their ability to combat cancer metastasis.
Tsz Long Chu, Peikai Chen, Anna Xiaodan Yu…·Kathryn S.E. Cheah
The paper identifies MMP14 as a regulator of PTH signaling in osteoblast lineage cells, showing that MMP14 cleavage of PTH1R reduces signaling intensity, promoting bone anabolism.
Minxian Qian, Zuojun Liu, Linyuan Peng…·Baohua Liu
The paper shows that boosting ATM activity with chloroquine extends lifespan in nematodes and mice by improving DNA repair and metabolic health.