Yanfei Zhang

The paper presents 320 nearly-complete East Asian genome assemblies, revealing new genetic diversity and structural variations not present in existing global pangenomes.

This study identifies 31 plasma proteins and expands genetic loci associated with PCOS, highlighting metabolic and hormonal influences and polygenic risk effects on cardio-metabolic outcomes.

This paper identifies prediction anomalies in a constraint-based metabolic model by incorporating enzyme compartmentalization, improving pathway structure accuracy and resolving constraint conflicts.

This study uses multivariable Mendelian randomization to show that higher bone mineral density causally increases osteoarthritis risk independently of body mass index.

The paper performs a genome-wide rare variant analysis across nine cancer types using germline WES data to identify cancer predisposition genes and pathways.

This study identifies genetic clusters associated with PCOS subtypes and finds causal links between BMI, SHBG, and PCOS.

This paper identifies novel genetic variants associated with PCOS using EHR-based GWAS and validates them in independent cohorts.

This study investigates the association between GSTM1 copy number and kidney failure risk in a large cohort, finding no significant association after adjustments.