ATF4 mediates fetal globin upregulation in response to reduced β-globin
Mandy Y. Boontanrart, Gautier Stehli, Marija Banović, Markus Schröder, Stacia K. Wyman, Rachel Lew, Matteo Bordi, Benjamin G. Gowen, Mark A. DeWitt, Jacob E. Corn
The paper identifies ATF4 as a key regulator of fetal globin re-expression in response to reduced β-globin, providing mechanistic insight into stress-induced globin compensation.
bioRxiv · Jan 15, 2020 · PreprintGenetics