Author

Rachel Lew

Gladstone Institutes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Organism:human· 1 Research Focus:protein design· 1

Frequent Co-Authors

Arik ShamsiD· 1 shared Benjamin G. GoweniD· 1 shared Benjamin L. Oakes· 1 shared Brett T. Staahl· 1 shared Christof FellmanniD· 1 shared David F. SavageiD· 1 shared Gautier StehliiD· 1 shared Jacob E. CorniD· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperMolecular Biology

Arik ShamsORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Comprehensive deletion landscape of CRISPR-Cas9 identifies minimal RNA-guided DNA-binding modules

Arik Shams, Sean A. Higgins, Christof Fellmann, Thomas G. Laughlin, Benjamin L. Oakes, Rachel Lew, Shineui Kim, Maria Lukarska, Madeline L. Arnold, Brett T. Staahl, Jennifer A. Doudna, David F. Savage

The paper uses a genetic minimization technique to identify minimal DNA-binding modules in Cas9, showing that large domain deletions can retain function.

Nature Communications · Sep 27, 2021Peer-reviewedMolecular Biology

ATF4 mediates fetal globin upregulation in response to reduced β-globin

Mandy Y. Boontanrart, Gautier Stehli, Marija Banović, Markus Schröder, Stacia K. Wyman, Rachel Lew, Matteo Bordi, Benjamin G. Gowen, Mark A. DeWitt, Jacob E. Corn

The paper identifies ATF4 as a key regulator of fetal globin re-expression in response to reduced β-globin, providing mechanistic insight into stress-induced globin compensation.

bioRxiv · Jan 15, 2020 · PreprintGenetics