Systems BiologybioRxivPreprint
Mapping intratumoral myeloid-T cell interactomes at single-cell resolution reveals targets for overcoming checkpoint inhibitor resistance
Kate Bridges, Gabriela A. Pizzurro, Alev Baysoy…·Kathryn Miller‐Jensen
The paper develops a computational method to analyze single-cell RNA-seq data to study cell-cell interactions in tumors, showing that CD40 agonist enhances immune checkpoint blockade by modulating myeloid-T cell interactions.