Author

Michael LaPorte

Salk Institute for Biological Studies

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Susan M. KaechiD· 3 shared Aaron P. HavasiD· 2 shared Adarsh RajeshiD· 2 shared Alessandra SaccoiD· 2 shared Armin GandhiiD· 2 shared Filipe Araujo HoffmanniD· 2 shared K. Garrett EvenseniD· 2 shared Kathryn LandeiD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCell Biology

Susan M. KaechORCID

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3 papers

Recent·Most cited

Aging-induced hepatocyte CD44 drives IL6/STAT3 signaling and associates with impaired neighboring T cell function.

Armin Gandhi, Kathryn Lande, Kelly Yichen Li, Filipe Araujo Hoffmann, Michael LaPorte, Shirong Tan, K. Garrett Evensen, Benji Portillo, Marcos G. Teneche, Rouven Arnold, Adarsh Rajesh, Jessica Proulx, Shanshan Yin, Aaron P. Havas, Angela Liou, , Peter D. Adams

This study shows that aging-induced CD44 in hepatocytes activates the IL6/JAK/STAT3 pathway, leading to impaired T cell function in the liver.

npj Aging · Aug 13, 2026Peer-reviewedCell Biology

Mapping intratumoral myeloid-T cell interactomes at single-cell resolution reveals targets for overcoming checkpoint inhibitor resistance

Kate Bridges, Gabriela A. Pizzurro, Alev Baysoy, Janani P. Baskaran, Ziyan Zoe Xu, Varsha Mathew, Victoria Tripple, Michael LaPorte, Koonam Park, William Damsky, Harriet M. Kluger, Rong Fan, Susan M. Kaech, Marcus Bosenberg, Kathryn Miller‐Jensen

The paper develops a computational method to analyze single-cell RNA-seq data to study cell-cell interactions in tumors, showing that CD40 agonist enhances immune checkpoint blockade by modulating myeloid-T cell interactions.

bioRxiv · Oct 28, 2024 · PreprintSystems Biology

Activated Interferon Signaling Suppresses Age-Dependent Liver Cancer

Aaron P. Havas, Kathryn Lande, Adarsh Rajesh, K. Garrett Evensen, Siva Karthik Varanasi, Linshan Shang, Elizabeth K. Schmidt, Jin Lee, Kenneth H. Kim, Marcos Garcia Teneche, Filipe Araujo Hoffmann, Michael LaPorte, Andrew E. M. Davis, Abby Grier, Julie A. Reisz, , Peter D. Adams

This study shows that aged livers have heightened interferon signaling that suppresses cancer but also has harmful effects, leading to a 'precarious balance' in tumor development.

bioRxiv · Jul 31, 2024 · PreprintCancer Biology