Marcus Bosenberg

This study shows that tumor cell-intrinsic mtDNA instability drives temporal changes in the melanoma immune microenvironment through cGAS, affecting immune cell states and therapeutic response.

This study shows that inhibiting DNMT1 improves CD8+ T cell function in the tumor microenvironment and enhances the effectiveness of immune checkpoint inhibitors in a melanoma model.

This study identifies clonal determinants of liver metastasis and poor survival in uveal melanoma by analyzing genomic and transcriptional features of primary and metastatic tumors.

The paper uses patient tumor samples to identify lineage- and context-specific mechanisms of innate immune resistance through perturbational single-cell RNA sequencing.

The paper develops a computational method to analyze single-cell RNA-seq data to study cell-cell interactions in tumors, showing that CD40 agonist enhances immune checkpoint blockade by modulating myeloid-T cell interactions.