Author

Roba Abukwaik

King Abdulaziz UniversityORCID 0000-0002-4769-6231Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Organism:human· 1 Approach:statistical model· 1

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Daniel A. TennantiD· 1 shared Elías Vera-SigüenzaiD· 1 shared Fabian SpilliD· 1 shared

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2024-2024 · peak 1/yr

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3 top collaborators · 3 mutual co-author links

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1 shared paperCancer Biology

Daniel A. TennantORCID

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1 paper

Recent·Most cited

Cancer BiologyBulletin of Mathematical BiologyPeer-reviewedAug 29, 2024

P53 Orchestrates Cancer Metabolism: Unveiling Strategies to Reverse the Warburg Effect

Roba Abukwaik, Elías Vera-Sigüenza, Daniel A. Tennant, Fabian Spill

This study develops a mathematical model of p53's role in reversing the Warburg effect by modulating cancer metabolism, showing that p53 activation can restore OXPHOS and that targeting glycolysis may be more effective than targeting SCO2 in p53-mutated cancers.

20 citations

humanstatistical model

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