Daniel A. Tennant

The paper shows that tissue-wide metabolic buffering allows neural stem cells to maintain proliferation despite mitochondrial dysfunction, highlighting the role of tissue heterogeneity in resilience.

The paper develops a mechanistically derived model of SLC25A10 transport, incorporating competitive binding and electroneutrality, and validates it with experimental data.

This study identifies mitochondrial metabolism as a key factor in 5-fluorouracil resistance in colorectal cancer and shows that targeting mitochondrial Complex I can enhance chemotherapy effectiveness.

This paper shows that asparagine enables transsulfuration to restore redox balance in tumors lacking aspartate synthesis enzymes, highlighting transsulfuration as a targetable vulnerability.

This study identifies GBP5's role in enhancing glycolysis and maintaining Golgi integrity in IFNγ-stimulated macrophages.

This study shows iron deficiency impairs CD8+ T cell proliferation and metabolism by disrupting mitochondrial function, but exogenous aspartate can rescue this defect.

This study uses a mathematical model to explore how chromaffin cells maintain electron transport chain function despite SDH-b loss, revealing mechanisms that support cell survival.

This study develops a mathematical model of p53's role in reversing the Warburg effect by modulating cancer metabolism, showing that p53 activation can restore OXPHOS and that targeting glycolysis may be more effective than targeting SCO2 in p53-mutated cancers.

This study shows that pyruvate from bone marrow mesenchymal stem cells supports myeloma cell redox homeostasis and anabolism through MCT-1/2 transporters.