Weckle is a molecular switch that diverts Toll signalling from innate immunity towards growth by engaging Yki
D. Perez-Sanchez, Guiyi Li, Martin C. Moncrieffe, Francisca Rojo-Cortés, Karina Malinovska, Emily Sample, Myles Maddick, Marta Moreira, Elizabeth C Connolly, Anna Parsons, Roberto Feuda, Nicholas J. Gay, Alicia Hidalgo
This paper identifies Weckle as a molecular switch that redirects Toll signalling from innate immunity to growth by interacting with Yki, revealing a mechanism for brain plasticity and potential implications for regeneration and cancer.
bioRxiv · Feb 20, 2026 · PreprintDevelopmental Biology