Gregory S.X.E. Jefferis

Evolutionary diversification of shared brain and nerve cord neuronal populations in Drosophila melanogaster

The paper identifies serial homology between neuronal populations in the Drosophila melanogaster brain and ventral nerve cord using lineage reporters, single-cell transcriptomics, and a connectome.

Structured Connectivity Across Multiple Drosophila Mushroom Bodies

The paper identifies structured connectivity patterns in Drosophila mushroom bodies across multiple connectomes, showing reproducible pathways that prioritize food-related sensory information.

A Developmental Atlas of the Drosophila Nerve Cord Uncovers a Global Temporal Code for Neuronal Identity

This paper presents a high-resolution developmental transcriptional atlas of the Drosophila nerve cord, identifying three principles governing neuronal diversity and sex-specific differences.

VFB-MCP: Natural-Language Access to Drosophila Neuroscience Grounded by an Expert-Curated Ontology-Led Knowledgebase

Model Context Protocol tools over Virtual Fly Brain's graph let Claude answer 25/30 Drosophila neuroscience tasks precisely, vs 14/30 with web search, 2/30 bare.

Distributed control circuits across a brain-and-cord connectome

The paper presents the first densely reconstructed adult fruit fly connectome integrating the brain and ventral nerve cord, revealing distributed control circuits involving local and long-range neural connections.

From Sensory Detection to Motor Action: The Comprehensive Drosophila Taste-Feeding Connectome

This paper maps the complete Drosophila male gustatory system connectome, revealing GRN diversity and sensory-to-motor pathways for feeding and social behaviors.

Sexually dimorphic neurons in the Drosophila whole-brain connectome

The paper identifies and analyzes sexually dimorphic neurons in the Drosophila brain using connectome data to understand their connectivity and functional roles in behavior.

Connectome-driven neural inventory of a complete visual system

A FIB-SEM connectome of the male Drosophila right optic lobe sorts ∼53,000 neurons into 727 types, with neurotransmitter predictions and 577 matched split-GAL4 lines.

An updated catalogue of split-GAL4 driver lines for descending neurons in Drosophila melanogaster

The paper updates a catalogue of split-GAL4 driver lines for descending neurons in Drosophila melanogaster by adding new cell types and driver lines.

A neurotrophin functioning with a Toll regulates structural plasticity in a dopaminergic circuit

This study shows that DNT-2 and its receptors Toll-6 and Kek-6 regulate structural plasticity in dopaminergic circuits in Drosophila, affecting behavior and connectivity.

Quantitative Attributions with Counterfactuals

This paper introduces QuAC, a method for explaining deep neural network decisions on images by generating counterfactuals and attributing class differences, and evaluates it on synthetic and biological datasets.

Neuronal wiring diagram of an adult brain

The paper presents the first neuronal wiring diagram of a whole adult Drosophila brain, revealing synaptic connections and circuit mechanisms underlying sensorimotor behaviors.

A leaky integrate-and-fire computational model based on the connectome of the entire adult Drosophila brain reveals insights into sensorimotor processing

The paper creates a computational model of the Drosophila brain connectome to study sensorimotor processing and validates predictions through experiments.

Neuronal "parts list" and wiring diagram for a visual system

The paper completes the list of cell types in the Drosophila optic lobe and identifies connectivity rules, revealing new families and clusters related to visual functions.

Neural circuit mechanisms underlying context-specific halting in Drosophila.

This study identifies two distinct neural mechanisms for context-specific halting in Drosophila during feeding and grooming behaviors.

Network Statistics of the Whole-Brain Connectome of Drosophila

The paper analyzes the network properties of the Drosophila whole-brain connectome, identifying rich club organization and signal integration/broadcasting neurons.

Comparative connectomics of the descending and ascending neurons of the Drosophila nervous system: stereotypy and sexual dimorphism

The paper provides a connectomic description of ascending and descending neurons in the Drosophila nervous system, revealing sexual dimorphism and motor-related circuits.

Neurotransmitter Classification from Electron Microscopy Images at Synaptic Sites in Drosophila Melanogaster

The paper uses artificial neural networks to classify neurotransmitters from electron microscopy images of Drosophila melanogaster synapses, achieving high accuracy and revealing ultrastructural differences.

From connectome to effectome: learning the causal interaction map of the fly brain

The paper introduces a method to learn a causal model of the fly brain using a connectome and optogenetic perturbation data, revealing that global brain dynamics arise from small, localized circuits.

Whole-brain annotation and multi-connectome cell typing quantifies circuit stereotypy in Drosophila

Annotating the 127,978-neuron FlyWire fly connectome yields 4,552 cell types, 3,094 cross-validated against the hemibrain; cell-type edges above 10 synapses or 1.1% of input recur over 90% across hemispheres.

Transforming descending input into motor output: An analysis of the Drosophila Male Adult Nerve Cord connectome

1328 descending and 733 motor neurons of the male Drosophila nerve cord connectome were curated; direct links between them are infrequent, and intrinsic-neuron communities route control per motor system.

A Connectome of the Male Drosophila Ventral Nerve Cord

Roughly 23 thousand traced neurons and 10 million TBars of the male Drosophila nerve cord, reconstructed from electron microscopy, typed, and queryable in neuPrint down to motor neurons.

Systematic annotation of a complete adult male Drosophila nerve cord connectome reveals principles of functional organisation

The paper systematically annotates a complete adult male Drosophila nerve cord connectome, identifying neuron types, connectivity patterns, and sensory modalities to reveal organizational principles.

Generating parallel representations of position and identity in the olfactory system

The paper shows that Drosophila uses separate neural pathways to process spatial and qualitative information from the pheromone cVA, enabling context-dependent mating behaviors.

BigNeuron: A resource to benchmark and predict best-performing algorithms for automated reconstruction of neuronal morphology

BigNeuron benchmarks automatic neuron reconstruction algorithms using gold standard annotations and image quality metrics, showing that consensus methods outperform individual algorithms.

Chemoreceptor Co-Expression in Drosophila Olfactory Neurons

The paper maps chemosensory co-receptor expression in Drosophila olfactory neurons, revealing widespread co-expression patterns among Orco, Ir25a, Ir8a, and Ir76b.

Fly Cell Atlas: a single-cell transcriptomic atlas of the adult fruit fly

The paper creates a single-cell transcriptomic atlas of the adult fruit fly, identifying over 250 cell types and analyzing gene signatures and sexual dimorphism across tissues.

Circuits for integrating learnt and innate valences in the fly brain

The paper maps convergence neurons in Drosophila that integrate innate and learned olfactory drives to mediate action selection.

Information flow, cell types and stereotypy in a full olfactory connectome

The paper describes the Drosophila olfactory system using a connectome, identifies information flow patterns, and quantifies stereotypy across individuals.

Neural circuit basis of aversive odour processing in Drosophila from sensory input to descending output.

Geosmin avoidance in Drosophila runs from a labelled line at the periphery into a distributed central representation spanning 80 third-order cell types, then into specific descending neurons.