High salt induces cognitive impairment via the angiotensin II-AT1 and prostaglandin E2-EP1 systems
Hisayoshi Kubota, Kazuo Kunisawa, Bolati Wulaer, Masaya Hasegawa, Hitomi Kurahashi, Takatoshi Sakata, Hiroyuki Tezuka, Masanori Kugita, Shizuko Nagao, Taku Nagai, Tomoyuki Furuyashiki, Shuh Narumiya, Kuniaki Saito, Toshitaka Nabeshima, Akihiro Mouri
This study shows high salt intake causes cognitive impairment in mice through the angiotensin II-AT1 and prostaglandin E2-EP1 systems, which can be mitigated by losartan or EP1 gene knockout.
bioRxiv · Jun 6, 2022 · PreprintNeuroscience