Tomoyuki Furuyashiki

Synaptic mitochondrial oxidative stress drives individual variability in age-related cognitive decline in mice

This study identifies synaptic mitochondrial oxidative stress as a driver of individual variability in age-related cognitive decline in mice, showing that targeting mitochondria with MitoQ reduces cognitive decline.

Aging Converts Microglial Repopulation into Maladaptive Reprogramming that Exacerbates Cognitive Deficits

This study shows that microglial repopulation in aged mice leads to maladaptive gene expression changes and worsens cognitive decline, unlike in young mice.

Lateralized vagal oxytocin signaling separately controls feeding and socioemotional functions via hypothalamic oxytocin signaling

This study shows that left and right vagal oxytocin signaling differentially control feeding and socioemotional behaviors via hypothalamic oxytocin neurons in mice.

High salt induces cognitive impairment via the angiotensin II-AT1 and prostaglandin E2-EP1 systems

This study shows high salt intake causes cognitive impairment in mice through the angiotensin II-AT1 and prostaglandin E2-EP1 systems, which can be mitigated by losartan or EP1 gene knockout.