Hisayoshi Kubota

Developmental prefrontal myelination shapes inhibitory interneuron function and adult social behavior

This study shows that disrupting developmental myelination in the medial prefrontal cortex impairs adult social behavior and PV interneuron function in mice, with parallels in human schizophrenia.

KCNQ2/3 Regulates the Synaptic Remodeling Associated with Drug Seeking in Addiction

This study identifies KCNQ2/3 potassium channels as regulators of synaptic remodeling during withdrawal, showing their activation can suppress cocaine-seeking behavior.

Antipsychotic-like effects of the selective Rho-kinase 2 inhibitor KD025 in genetic and pharmacological mouse models of schizophrenia

This study shows that the selective ROCK2 inhibitor KD025 has antipsychotic-like effects and fewer side effects in schizophrenia models.

High salt induces cognitive impairment via the angiotensin II-AT1 and prostaglandin E2-EP1 systems

This study shows high salt intake causes cognitive impairment in mice through the angiotensin II-AT1 and prostaglandin E2-EP1 systems, which can be mitigated by losartan or EP1 gene knockout.