ALDH1B1 promotes mitochondrial γ-butyrobetaine biosynthesisand fatty acid oxidation in colorectal cancer
Zhiping Feng, Thomas E. Bearrood, Sydney L. Campbell, Adrianne M. Kinsey, Nedas Matulionis, Che‐Hong Chen, Takuya Seike, Logan B. Leak, Ahit Kaan Tarhan, Scott J. Dixon, Daria Mochly‐Rosen, Heather R. Christofk, James Chen
This study identifies ALDH1B1's role in mitochondrial GBB and GABA biosynthesis, enhancing fatty acid oxidation in CRC and linking it to tumor progression.
bioRxiv · Sep 25, 2026 · PreprintCancer Biology