James Chen

This study identifies cyanoquinoline-based HIPK4 inhibitors with nanomolar potency and reveals their cell-type-specific effects on HIPK4 proteostasis and autophagy.

This study identifies ALDH1B1's role in mitochondrial GBB and GABA biosynthesis, enhancing fatty acid oxidation in CRC and linking it to tumor progression.

The paper describes the development of AZ137, a potent and selective HIPK4 inhibitor derived from bosutinib, and validates its utility as a tool for studying HIPK4's biological functions.

This study shows HIPK4 is essential for spermiogenesis and male fertility in mice, with defects in sperm head morphology and fertility.

This paper develops a method for targeted cell ablation in zebrafish embryos using optogenetic transcriptional control combined with genetically encoded toxins and cis-regulatory elements.

This study uses a CRISPR-based screen to identify genes critical for Hedgehog signaling and ciliary function, revealing novel components of ciliary structures and linking congenital heart defects to ciliopathies.