Daria Mochly‐Rosen

ALDH1B1 promotes mitochondrial γ-butyrobetaine biosynthesisand fatty acid oxidation in colorectal cancer

This study identifies ALDH1B1's role in mitochondrial GBB and GABA biosynthesis, enhancing fatty acid oxidation in CRC and linking it to tumor progression.

Natural variants in SARS-CoV-2 S protein pinpoint structural and functional hotspots; implications for prophylaxis and therapeutics strategies

The paper analyzes SARS-CoV-2 Spike protein variants to identify structural and functional hotspots that impact transmission and therapeutic resistance.

Increased elastase sensitivity and decreased intramolecular interactions in the more transmissible SARS-CoV-2 variants' spike protein

The paper identifies increased elastase sensitivity and reduced intramolecular interactions in more transmissible SARS-CoV-2 variants' spike protein, suggesting potential treatment targets.

Paired SARS-CoV-2 Spike Protein Mutations Observed During Ongoing SARS-CoV-2 Viral Transfer from Humans to Minks and Back to Humans

The paper analyzes SARS-CoV-2 mutations in human and mink populations, showing mutations in the spike protein RBD transfer between species.

Phenotyping aldehyde metabolism in humans uncovers novel genetic mutations in aldehyde dehydrogenase 2

The paper develops a method to phenotype ALDH2 genetic differences in humans and identifies novel mutations causing inefficient acetaldehyde metabolism after alcohol consumption.