Scott J. Dixon

This study identifies ALDH1B1's role in mitochondrial GBB and GABA biosynthesis, enhancing fatty acid oxidation in CRC and linking it to tumor progression.

This study uses high-throughput spheroid profiling to show BMP2 and BMP4 rewire glioma cell death responses by suppressing standard therapies and priming for lipid-dependent necrosis.

The paper identifies metabolic differences between ASCL1-high and low SCLC cells, showing that ASCL1-high cells resist ferroptosis via BH4/BH2 antioxidants and are vulnerable to combined cysteine depletion and BH4/BH2 inhibition.

This study investigates how proteasome inhibition affects ferroptosis sensitivity using combined experimental and modeling approaches, revealing both sensitizing and desensitizing effects on different ferroptosis triggers.

This study shows that combining BRAFV600E inhibition with ferroptosis induction synergistically kills anaplastic thyroid cancer cells by increasing iron and oxidative stress.

This study shows that larger cells are more resistant to ferroptosis due to higher glutathione levels and lower lipid peroxides.

This study shows that GPX4 inhibitor sensitivity differs between 2D and 3D cultures due to lipid composition changes, with 3D cultures showing resistance through PUFA displacement by MUFAs.

The paper constructs a genome-scale genetic interaction network from 4 million double mutants in HAP1 cells, revealing conserved genetic network principles across species and uncovering novel gene functions and cancer dependencies.

This study investigates the Zdhhc5-GOLGA7 protein complex involved in non-apoptotic cancer cell death induced by CIL56, revealing key residues critical for complex formation and cell death.

The paper identifies ferroptosis regulators using a compendium of kinetic cell death modulatory profiles from 1,833 small molecules.